Sarah Ford | April 17, 2014

Researcher to Study Bone Fractures in Pediatric and Adolescent Cancer Survivors

Study could lead to treatment interventions

Researchers and physicians know that children who undergo cancer treatment are at risk for decreased bone mineral density because many cancer treatments negatively affect bone health. It is particularly important that children and adolescents develop strong bone density because bone strength decreases in adulthood. Despite this knowledge, little is known about the rate at which fractures actually occur in survivors of childhood cancer and if they can be prevented.

Lynda Vrooman, MD, MMSc of Dana-Farber Cancer Institute is a CureSearch Young Investigator interested in better defining the risks and long-term consequences of fracture in survivors of childhood cancer, and in intervening to minimize long-term complications. During her first year of research, Dr. Vrooman completed enrollment of 193 patients in a study of reported bone fracture. Her findings demonstrate that approximately 25% of cancer survivors experienced at least one fracture after cancer treatment. Of those with fracture, 35% experienced more than one fracture after treatment. In addition, survivors treated with corticosteroids, commonly used in the treatment of many types of children’s cancer, experienced significantly higher rates of fracture after cancer treatment. These results highlight the importance of minimizing the bony complications associated with corticosteroids and suggest that a treatment-associated fracture risk may extend beyond cancer therapy completion.

In the next year of her work, Dr. Vrooman will conduct detailed bone density testing in childhood cancer survivors with a history of fracture. Dr. Vrooman anticipates that this work will inform future interventional studies aimed at decreasing skeletal toxicity in survivors of childhood cancer.

>> Continue Reading

>> Support CureSearch’s Work With a Donation

Get Our Fundraising Insights Straight To Your Inbox

Explore More Articles

Funds Management Associate

February 24, 2024

Department:  Charitable Funds Management Solutions We are a non-profit charitable organization looking for skilled individuals who can coordinate multiple client requirements related to fund processing…

Read Article
World Sleep Day

World Sleep Day

February 20, 2024

World Sleep Day, which takes place on March 15th in 2024 ( March 14, 2025 for those who like to plan ahead), was founded by…

Read Article
EMP. App. Day

Employee Appreciation Day

February 20, 2024

Taking place on the first Friday of March each year, Employee Appreciation Day is the perfect time to show your gratitude for the hardworking staff…

Read Article

Get Resources and Insights Straight To Your Inbox

Receive our monthly/bi-monthly newsletter filled with information about causes, nonprofit impact, and topics important for corporate social responsibility and employee engagement professionals, including disaster response, workplace giving, matching gifts, employee assistance funds, volunteering, scholarship award program management, grantmaking, and other philanthropic initiatives.

newsletter-mock