Sarah Ford
Compound Restores Memory Function in Mouse Alzheimer’s Model
Researchers from Yale School of Medicine have discovered a promising new drug compound that reverses some Alzheimer’s effects on memory in mice.
The work directly stems from a 2008-11 BrightFocus grant to Paul Lombroso, MD, who’s on the Yale neurobiology and psychiatry faculty and directs its Laboratory of Molecular Neurobiology. He is senior author of a report published in PLoS Biology August 5.
They found that a protein drug compound, known as TC-2153, blocks the Alzheimer’s disease linked effects of another protein called striatal-enriched tyrosine phosphatase (STEP). At high levels, STEP prevents synaptic strengthening in the brain—something vital to memory function.
It’s actually one of several breakthroughs tied to this BrightFocus grant, which included 2000 Nobel Laureate Paul Greengard, PhD, of Rockefeller University, as coinvestigator. Four years ago…
Get Resources and Insights Straight To Your Inbox
Explore More Articles
Corporate Volunteering: The Business Case for an Employee Volunteer Program
Corporate volunteering has evolved well beyond the occasional company service day. A well-designed employee volunteer program can strengthen employee engagement, reinforce company culture, develop leadership skills,…
Environmental Awareness Month
Every September, environmental organizations around the Nation come together in recognition of Environmental Awareness Month, with a goal to raise awareness about environmental issues that…
Join Feeding America and Take Action During Hunger Action Month
No one should have to go hungry in the richest country in the world — yet millions of Americans don’t have enough to eat. Our…
Get Resources and Insights Straight To Your Inbox
Receive our monthly/bi-monthly newsletter filled with information about causes, nonprofit impact, and topics important for corporate social responsibility and employee engagement professionals, including disaster response, workplace giving, matching gifts, employee assistance funds, volunteering, scholarship award program management, grantmaking, and other philanthropic initiatives.
